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KMID : 0370220120560050304
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Yakhak Hoeji
2012 Volume.56 No. 5 p.304 ~ p.308
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In vitro and In vivo Activity of DW286, an Experimental Fluoronaphthyridione, against Gram-Positive Bacteria
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Kwak Jin-Hwan
Park Hee-Soo
Jung Sung-Ji
Jeong Ji-Woong
Kim Jo-Seph
Choi Dong-Rack
Choi Eung-Chil
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Abstract
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In vitro antibacterial activity of DW286 was tested against recently collected clinical isolates of Gram-positive strains by the two fold agar dilution method. In vivo activity of DW286 was also determined against systemic infections in mice caused by Staphylococcus aureus. DW286 showed 16~64-fold more potent in vitro activities than ciprofloxacin against Gram-positive bacteria. Against systemic infection model caused by two S. aureus strains, one being methicillin-susceptible and the other methicillin-resistant, DW286 (ED50s, 0.16 mg/kg and 4.36 mg/kg, respectively) was more potent than gemifloxacin (1.37 mg/kg, 26.58 mg/kg, respectively).
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KEYWORD
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DW286, fluoroquinolone, MIC, ED50
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